Physical Sciences Building
Room 339 (lab) / 354 (office)
1156 High Street
Santa Cruz, CA 95064
Chemistry and Biochemistry
© 2008 The Regents of the University of California
Maintained by ngassner@ucsc.edu
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UCSC Chemical Screening Center Current Equipment
The UCSC Chemical Screening Center instrumentation includes liquid handling robots, automated bulk dispensers to plate-out compounds/reagents , low and high volume pin tools and high-throughput plate readers to measure assay readout. A robotic high-content screening microscope is capable of performing multi-wavelength fluorescence imaging of adherent cells in multi-well plates. Computational image analysis allows cell-based high-content phenotypic screening. Data analysis may be carried out using a suite of programs available through the Center.
| Model | Description |
|---|---|
| Compound Libraries | Over 55,000 compounds from commercial sources and a unique growing collection of marine and terrestrial natural products. A listing of our current compound collection is available for download on our documents page. |
| Perkin-Elmer EnVision | Fast, state-of-the-art plate reader with plate stacker. Has absorption, fluorescence, ultrasensitive luminescence, and fluorescence polarization modes. |
| Molecular Devices ImageExpress | An automated microscope for high content screening. Nikon objectives, up to 60x, with bright fiber optic light source, robotic stage that accommodates multi-well plates and slides, and image analysis software. |
| BioTek plate washer | This plate washer is capable of aspirating liquids from 384- and 96-well plates, with plate stacker for walk-away HT applications. |
| Matrix WellMate | Automated peristaltic dispenser with plate stacker. Digitally operated, rapidly dispenses reagents/buffers into 384- and 96-well plates. |
| Perkin Elmer Janus MDT | This robotic liquid handler performs X-Y-Z robotic functions using a head equipped with a 96-channel pipette for reformatting libraries and high throughput compound addition. It also has a 384-pin tool capable of delivering 100 nL volume transfers to multi-well plates (either 384 or 1536). |
| Perkin Elmer Janus Varispan | This is an X-Y-Z robotic liquid handler capable with an independently controllable 8-tip pipet, used for performing serial dilutions, compound cherry picking, and any other routine automated liquid handling task. |
The Chemical Screening Center is funded by grants from the National Institutes of Health, the U.S. Department of State, and the California Institute for Quantitative Biomedical Research.